Joachim Antonisz. Wtewael is considered to be one of the last Dutch Mannerist painters. While living and working in Utrecht, his paintings reveal the influence of his trips to France and Italy as well as that of earlier painters. Wtewael frequently executed several versions of the same subject with only slight modifications to some elements in the composition. He also experimented with different supports and formats and achieved a brilliant level of technical mastery. Following the example of the Haarlem painters, his paintings became less ornate although they always retained a certain artificiality. In this work on copper Wtewael depicts the Holy Family in a natural setting, accompanied by saints and angels. On the right is the Virgin with the Infant Christ on her lap. To one side is the Infant Saint John the Baptist with the Lamb and Saint Elizabeth, and on the other, Saint Joseph who looks out at the viewer. Behind the group are two musical angels while on the left we see the Apostle Simon, also known as Simon Zelotes, holding a saw. Next to Simon is an angel with a basket of fruit. The composition rises up in a pyramidal shape with three playful, flying angels at the top next to the central tree. The painting can be related to another on the same subject, albeit on canvas and larger in size, now in the Musée de Picardie, Amiens.